Langerhans Cell Histiocytosis
DOI:
https://doi.org/10.47990/alop.v7i2.141Keywords:
infants, Langerhans cell histiocytosis, periodontitis, oral manifestationsAbstract
Langerhans cell histiocytosis (LCH) is a rare idiopathic disease characterized by the clonal proliferation of Langerhans cells. LCH may appear as a single osteolytic lesion or can affect many body systems. Oral involvement may predate systemic manifestations or mimic infectious/inflammatory disorders. This case report involves a 3-year-old boy referred to the pediatric dentistry residency clinic at the University of Puerto Rico to evaluate possible periodontal disease on primary second lower molars. Examination revealed bilateral extra-oral swelling on the left and right side of the face obliterating the mandibular angles. The overlying skin was intact and symptomless. An intraoral examination showed localized swelling of the overlying mucosa from the lower primary right and left molars with some degree of mobility on both the right and left second primary molars. This case illustrates the need for pediatricians and pediatric dentists to be aware of LCH mimicking periodontal lesions.
References
Alshadwi, A., Nadershah, M., & AlBazie, S. (2013). Langerhans cell histocytosis of the mandible in a pediatric patient. Journal of Dentistry for Children (Chicago, Ill.), 80(3), 145–9. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24351696
Divya, K. S. (2014). Oral manifestion of Langerhans cell histiocytosis mimicking inflammation. Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research, 25(2), 228–30. http://doi.org/10.4103/0970-9290.135930
Eckardt, A., & Schultze, A. (2003). Maxillofacial manifestations of Langerhans cell histiocytosis: a clinical and therapeutic analysis of 10 patients. Oral Oncology, 39(7), 687–94. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12907208
Madrigal-Martínez-Pereda, C., Guerrero-Rodríguez, V., Guisado-Moya, B., & Meniz-García, C. (2009). Langerhans cell histiocytosis: literature review and descriptive analysis of oral manifestations. Medicina Oral, Patología Oral Y Cirugía Bucal, 14(5), E222–8. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19218906
Minkov, M. (2011). Multisystem Langerhans cell histiocytosis in children: current treatment and future directions. Paediatric Drugs, 13(2), 75–86. http://doi.org/10.2165/11538540-000000000-00000
Shirley, J. C., & Thornton, J. B. (2000). Oral manifestations of Langerhans’ cell histiocytosis: review and report of case. ASDC Journal of Dentistry for Children, 67(4), 293–6. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10997248
Slater, J. M., & Swarm, O. J. (1980). Eosinophilic granuloma of bone. Medical and Pediatric Oncology, 8(2), 151–64. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/6999317
Society, W. G. of the H. (1987). Histiocytosis syndromes in children. Lancet, 1(8526), 208–9. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2880029
Yashoda-Devi, B., Rakesh, N., & Agarwal, M. (2012). Langerhans cell histiocytosis with oral manifestations: a rare and unusual case report. Journal of Clinical and Experimental Dentistry, 4(4), e252–5. http://doi.org/10.4317/jced.50728
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