Antibacterial efficacy of two mouthwashes (Triclosan and Cetylpyridinium Chloride) against oral Streptococci

Abstract

The aim of this research was to evaluate the antimicrobial activity of two oral antiseptics against oral streptococcus. A clinical, prospective and longitudinal study was carried out in a sample of 45 patients. Methods: Male and female subjects from 21 to 35 years old were included in this research. They were randomly selected in three groups; group 1 (Cetylpyridinium Chloride), group 2 (Triclosan), and group 3 (Water) as a control. A questionnaire regarding daily oral hygiene habits and an odontogram to determine caries risk was performed before using any mouthrinse. Likewise, saliva was collected with the aim to calculate the initial CFU/ml of oral streptococci. Eventually, saliva samples were collected to count post-rinse CFU/ml of oral streptococci and contrast it with the initial sample. Final results showed that the use of either triclosan or cetylpyridinium chloride reduce significantly the CFU/ml of oral streptococci. The average reduction on the triclosan group was 146,200 CFU/ml whereas it was 113,670 CFU/ml on cetylpyridinium chloride group. Furthermore, a significant association amongst the sort of saliva, the number of decay surfaces, and the initial CFU/ml of oral streptococci was found. (p<0.05) It was concluded under experimental verification that triclosan is more effective than cetylpyridinium chloride. Therefore, as a result a statistical significance between the two mouthwashes was demonstrated.